The coronavirus disease 2019 (COVID-19) pandemic has exposed scientific uncertainty in its raw form. When facts are uncertain, policy makers and health experts sometimes shy away from communicating scientific uncertainty, fearing that the uncertainty will generate mistrust. In Germany, for instance, the pandemic-related threat scenarios invoked have sometimes been devoid of uncertainty. Nevertheless, presenting uncertain aspects of the pandemic as certain may adversely affect citizens’ trust and compliance with containment measures should those reports later prove invalid. We assessed people’s preferences for health communications with varying degrees of scientific uncertainty in the context of the COVID-19 pandemic and explore factors associated with the preferred form of communication.