The Internet gives patients the opportunity to be better informed, have ownership over their data, and, therefore, be empowered in the medical decision-making process. All of these new forms of patient empowerment through eHealth, however, require the patients’ trust in online service. Existing literature provides a solid foundation regarding the development of trust in social encounters. What is more, the understanding of trust related to more general online services, such as e-commerce is advanced, too. Regarding eHealth in particular, however, there are substantial gaps in the literature.